Programme Steering Committee
Professor Amrita Ahluwalia
Professor of Vascular Pharmacology, Co-Director of The William Harvey Research Institute
Professor Panos Deloukas
Professor of Cardiovascular Genomics
Professor Federica Marelli-Berg
BHF Professor of Cardiovascular Immunology
Professor Andrew Tinker FMedSci
Professor of Cardiac Electrophysiology
Professor Tim Warner (co-ordinator of programme)
Professor of Vascular Inflammation
Named Programme Supervisors
Amrita Ahluwalia - Professor of Vascular Pharmacology
Research Field: Investigations into the role of vascular inflammation in the pathogenesis of cardiovascular disease. The biology of nitrates and the pharmacology of bradykinin receptors in controlling cell trafficking and vascular reactivity.
Michael R. Barnes - Director of Bioinformatics, NIHR Cardiovascular BRU
Research Field: Computational Biology and Bioinformatics focused on Drug Discovery and Translational Research, building on 14 years pharma R&D experience. Active research across multidisciplinary fields, including systems biology and pathway approaches to the analysis of genetic and genomic data for target discovery, drug repositioning and biomarker identification. Development of cardiovascular clinical databases enabling data integration for stratified medicine development. Studies of cardiovascular disease pathology and drug pharmacogenetics using next-generation sequencing technologies (RNA-seq, Exomes, Chip-seq, Whole genomes).
Mark Caulfield FMedSci - Professor of Clinical Pharmacology
Research Field: Translational research programme is focused on elucidating the genetic basis of blood pressure and related phenotypes with the aim of identifying new therapies and translating them into clinical trials.
Adrian Hobbs – Professor of Cardiovascular Pharmacology
Research Field: The physiological and pathological actions and interactions of guanylate cyclases in the cardiovascular system. Impact on pulmonary artery hypertension and systemic blood pressure. Investigation on the patho-pharmacology of natriuretic peptides.
Kairbaan Hodivala-Dilke - Professor of Angiogenesis
Research Field: Angiogenesis, the formation of new blood vessels from pre-existing ones, is essential for tumour growth and cancer spread. Modulation of angiogenesis is therefore a logical approach to cancer treatment. Our research aims to examine the molecular mechanisms underlying angiogenesis, vascular leakage and lymphangiogenesis, using a combination of endothelial-, pericyte and lymphatic endothelial-specific knock-out and knock-in systems in mouse models of cancer and other vascular diseases, and ex vivo angiogenesis assays and analysis of the cellular and molecular mechanisms behind these observations.
David Lee - Professor of Cell & Tissue Engineering
Research Field: Investigating the effects of mechanical loading on cell function, including elucidation of the mechanisms of mechanical transfer and transduction to induce alterations in gene expression.
David Kelsey - Professor of Human Molecular Genetics
Research Field: Work primarily focuses on the molecular mechanisms underlying primarily inherited monogenic disease. This has led to a number of key scientific findings including the first association of GJB2 mutations with recessive hearing loss, (making the link between desmosome mutations with skin disease and cardiomyopathy), identification of the Harlequin Ichthyosis gene, RSPO4 as a key molecule in nail development and functional studies of connexins in epithelial biology.
Federica M. Marelli-Berg - Professor of Cardiovascular Immunology
Research Field: Investigations into the dynamics and mechanisms of regulatory and memory T cell trafficking.
Anthony Mathur - Professor of Cardiology
Research Field: Translational cardiology targeting new biological and interventional approaches to the ‘no option patient’. Stem cell therapy for cardiac disease.
Claudio Mauro - Senior Lecturer & British Heart Foundation Intermediate Fellow
Research Field: Mechanisms by which metabolic alterations in cardiovascular metabolic diseases lead to aberrant T cell responses and migration patterns, which favour the establishment of chronic inflammation. Research is exploring the mechanisms of metabolic control of T cell-mediated immune responses, including migration, differentiation and cytokine production in physiology and under metabolic stress.
Patricia Munroe - Professor of Molecular Medicine
Research Field: Determination of the genetic and molecular basis of hypertension and cardiac arrhythmias.
Sussan Nourshargh FMedSci - Professor of Microvascular Pharmacology
Research Field: Investigations into the mode, dynamics and mechanisms of leukocyte transmigration as induced by physiological and pathological inflammation.
Mauro Perretti - Professor of Immunopharmacology
Research Field: Pioneered the concept of endogenous anti-inflammatory and pro-resolving mediators and pathways, studying the impact they may have on the immune response with a focus on vascular reactivity. Our lab has established expertise in the running of in-vivo models of inflammation, spanning from protocols to study leukocyte recruitment to models of ischaemia-reperfusion, Intravital microscopy, together with deep analyses of neutrophil biology in static and under flow condition. In the last years, developed an interest in the exploitation of novel ligands toward anti-inflammatory GPCRs as novel therapeutic entities, together with an interest in the biology of leukocyte-derived microparticles.
Steffen Petersen – Professor of Cardiovascular Medicine
Research Field: At Barts Health we currently have 2 dedicated CMR scanners (3-4000 scans per year), 1 dedicated state of the art cardiac CT scanner (1800 scans per year) and access to PET/CT. With this year to year increasingly large image "biobank" of heart muscle disease and coronary artery disease, PhD fellowships could include developing new image analysis tools, setting up of cardiac atlases in collaboration with our bioengineering and bioinformatics teams.
Richard Schilling - Professor of Cardiology and Electrophysiology
Research Field: Investigating mechanisms and invasive therapies for complex cardiac arrhythmia.
Gleb Sukhorukov - Professor of Biomedical Materials
Research Field: Multifunctional delivery systems, Remote guided capsules and particles, Remote controlled activation of drugs, Micro- and nanoencapsulation, Thin functional films and biofunctionalisation of surfaces, particles and delivery vesicles.
Ken Suzuki - Professor of Translational Cardiovascular Therapeutics
Research Field: Translational research to develop novel approaches for treating heart failure, including cell-based therapy, gene therapy and regenerative therapy. Also developing interest in TRL signalling in cardiomyocytes.
Christoph Thiemermann FMedSci - Professor of Pharmacology
Research Field: Investigations into the pathophysiology leading to the circulatory failure and organ dysfunction associated with ischaemia/reperfusion and shock of myocardial infarction, heart failure, sepsis, trauma-haemorrhage, acute kidney injury and chronic kidney disease. In particular, investigation of novel treatment strategies on molecular pathways to maintain organ integrity and function during disease states.
Adam Timmis - Professor of Clinical Cardiology
Research Field: National cardiovascular registries: linkage, aetiological and prognostic studies of the coronary journey
Andrew Tinker FMedSci - Professor of Cardiac Electrophysiology
Research Field: Role potassium channels and cell signalling proteins play in cardiac (patho)physiology. The question is how these might act to reinforce normal heart rhythm or act as substrates for cardiac arrhythmia. We have specific interests in a range of potassium channels and heterotrimeric G-protein signalling in the heart and blood vessels. Technically we are using unique strains of genetically modified mice either generated by ourselves and\or provided by collaborators. We combine this with complex murine phenotyping capabilities including ex-vivo single-cell electrophysiology and imaging of cardiac myocytes (ventricular, atrial and SA nodal), in-vivo telemetry in awake conscious mice to measure heart rate, heart rate variability and document abnormal rhythm, blood pressure and in-vivo electrophysiology studies with programmed electrical stimulation to induce arrhythmia. We have an established track record in molecular and cellular studies. I have several distinctive research strands being pursued in my laboratory with work on ATP-sensitive K+ channels, G-protein gated inwardly rectifying K+ channels and cardiac channelopathies
Tim Warner - Professor of Vascular Inflammation
Research Field: Investigations into influences of prostanoids and other vascular mediators on platelet and blood vessel wall reactivity.
Muhammad Magdi Yaqoob - Professor of Nephrology
Research Field: Pathogenesis of acute and chronic uraemia (with and without diabetes) and its complications (cardiovascular, musculoskeletal, haematological, immunological and genetic). Investigations include the examination of downstream effects of acute and chronic kidney injury in clinical subjects and in experimental models, both in vivo and in vitro.